The hemidesmosome is a complex junction containing many proteins. The keratin cytoskeleton attaches to its cytoplasmic plaque, while its transmembrane elements interact with components of the extracellular matrix. Hemidesmosome assembly involves recruitment of α6β4 integrin heterodimers, as well as cytoskeletal elements and cytoskeleton-associated proteins to the cell surface. In our cell culture models, these phenomena appear to be triggered by laminin-5 in the extracellular matrix. Cell interaction with laminin-5 apparently induces both phosphorylation and dephosphorylation of subunits of α6β4 integrin. There (...) is emerging evidence that such events are necessary for subsequent cytoskeleton anchorage to the hemidesmosome cytoplasmic plaque. Once assembled, the hemidesmosome plays an essential role in maintaining firm epithelial adhesion to the basement membrane, with hemidesmosome disruption being a hallmark of certain devastating blistering diseases. However, the hemidesmosome is more than just a stable anchor, as it may also be the site of signal transduction, mediated by its α6β4 integrin component. This review discusses our current knowledge of the structure and assembly of the hemidesmosome. BioEssays 20:488–494, 1998. © 1998 John Wiley & Sons, Inc. (shrink)

Lawrence Johnson advocates a major change in our attitude toward the nonhuman world. He argues that nonhuman animals, and ecosystems themselves, are morally significant beings with interests and rights. The author considers recent work in environmental ethics in the introduction and then presents his case with the utmost precision and clarity. Written in an attractive, nontechnical style, the book will be of particular interest to philosophers, environmentalists and ecologists.

Focusing on Truth explores the question of what truth is, balancing historical with issue-orientated discussion. The book offers a comprehensive survey of all the major theories of truth. Lawrence Johnson investigates a number of closely related matters of truth in his inquiry, such as: What sorts of things are true or false? What is attributed to them when they are said to be true or false? What do facts have to do with truth? What can we learn from previous (...) theories? The book opens with an analysis of the coherence theory of truth and then the correspondence theory of truth, as developed by Moore, Russell and Wittgenstein. Through a study of the semantic conceptions of truth, the author reveals that an adequate theory of truth must take account of the pragmatics of person, purpose, and circumstance. A full understanding of facts and truth bearers is considered central to Johnson's criticism of the opposing truth theories of J. L. Austin and P. F. Strawson. Drawing on the merits of these theories and others, while identifying their deficiencies, Johnson presents a new account of truth, based on the correlation of referential foci and the use of linguistic conventions. This account is defended as being adequate to meet the legitimate demands made on a theory of truth. Johnson argues that the account leaves scope for statements of many different sorts to be true in their own widely varying ways, without the existence of a need to posit fundamentally different kinds of truth. (shrink)

I develop the thesis that species and ecosystems are living entities with morally significant interests in their own right and defend it against leading objections. Contrary to certain claims, it is possible to individuate such entities sufficiently well. Indeed, there is a sense in which such entities define their own nature. I also consider and reject the argument that species and ecosystems cannot have interests or even traits in their own right because evolution does not proceed on that level. Although (...) evolution proceeds on the level of the genotype, those selected are able to cooperate in entities of various higher orders—including species and ecosystems. Having their own nature and interests, species and ecosystems can meaningfully be said to have moral standing. (shrink)

Future generations do not exist, and are not determinate in their make-up. The moral significance of future generations cannot be accounted for on the basis of a purely individualistic ethic. Yet future generations are morally significant. The Person-Affecting Principle, that (roughly) only acts which are likely to affect particular individuals are morally significant, must be augmented in such a way as to take into account the moral significance of Homo sapiens, a holistic entity which certainly does exist. Recent contributions to (...) Environmental Values by Alan Carter and Ernest Partridge are criticised (but not entirely rejected). (shrink)

This book offers an introductory account of the central theories of truth. A wide range of theories, from those of correspondence and coherence to Tarski's semantic conception of truth are presented and assessed in order to profit from that which is of value in them. The authot proposes a new account which it is asserted is adequate to meet the legitimate demands made on the theory of truth.

Because higher education brings members of academic communities in direct contact with students, the reflective higher education student is in an excellent position for developing two important intellectual virtues: confidence and humility. However, academic communities differ as to whether their members reach consensus, and their teaching practices reflect this difference. In this essay, Ward Jones argues that both consensus‐reaching and non‐consensus‐reaching communities can encourage the development of intellectual confidence and humility in their students, although each will do so in (...) very different ways. (shrink)

In Stacked Deck, Mitchell shows us how this artificial reality buries the way we truly,live.Mitchell uses examples drawn from history, politics, law, and ...

“Whatever else of metaphysical or philosophical significance may be involved in a biblical pericope, it remains true that the writer or speaker was directing his words to something which he considered to be a vital element in the human situation, to understanding man's humanness as it finds expression in his life with others in a social context.”.

Cahoone carefully develops the idea of subjectivity and narcissism using psychological theory, the dialectical theory of the Frankfurt school, and historians.

The human race is an ongoing entity, not just a collection of individuals. It has interests which are not just the aggregated interests of individual humans. These interests are morally significant and have important implications for environmental ethics.

In _Civil Society_, Lawrence Cahoone stages a critical engagement between the social-political viewpoints of liberalism, communitarianism, and conservatism in order to effect a balanced relation that will bypass or overcome the inadequacies of each position.

The neologism post-truth is commonly used to characterize a polity in which false and biased beliefs have corrupted public opinion and policymaking. Simplifying and broadening our use of the adjective beyond its current narrow meaning could make post-truth a useful addition to the lexicons of history, politics, and philosophy. Its current use, however, is unhelpful and distracting (at best), and experienced as demeaning and humiliating (at worst). Contemporary polities are better characterized as post-trust. A polity becames post-trust when testimony from (...) either a community of knowledge workers or a social group of complainants—such as women who give testimony of sexual assault—loses influence upon public opinion and policymaking. (shrink)

Shaftesbury's Characteristics of Men, Manners, Opinions, Times was first published in 1711. It ranges widely over ethics, aesthetics, religion, the arts, and ancient and modern history, and aims at nothing less than a new ideal of the gentleman. Together with Locke's Essay Concerning Human Understanding and Addison and Steele's Spectator, it is a text of fundamental importance for understanding the thought and culture of Enlightenment Europe. This volume, first published in 2000, presents an edition of the text together with an (...) introduction, explanatory notes and a guide to further reading. (shrink)

Shaftesbury's Characteristics of Men, Manners, Opinions, Times was first published in 1711. It ranges widely over ethics, aesthetics, religion, the arts, and ancient and modern history, and aims at nothing less than a new ideal of the gentleman. Together with Locke's Essay Concerning Human Understanding and Addison and Steele's Spectator, it is a text of fundamental importance for understanding the thought and culture of Enlightenment Europe. This volume, first published in 2000, presents an edition of the text together with an (...) introduction, explanatory notes and a guide to further reading. (shrink)

Approaches bioethics on the basis of a conception of life and what is needed for the affirmation of its quality in the most encompassing sense. Johnson applies this conception to discussions of controversial issues in bioethics including euthanasia, abortion, cloning and genetic engineering. His emphasis is not on providing definitive solutions to all bioethical issues but on developing an approach to coping with them that can also help us deal with new issues as they emerge. The foundation of this discussion (...) is an extensive examination of the nature of the self and its good and of various approaches to ethics. His bioethic is integrally related to his well-known work on environmental philosophy. The book also applies these principles on an individual level, offering a user-friendly discussion of how to deal with ethical slippery slopes and how and where to draw the line when dealing with difficult questions of bioethics. (shrink)

In some part, the ideas presented here are anticipated in a paper by Frank Tillman, through I present a broader theory intended to have utility in connection with the theory of truth.

Examines the cultural implications of society's declining appreciation and recognition of common sense while exploring the process by which the concept is learned.